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Preparation and mechanical properties of poly(chitosan‐ g ‐ DL ‐lactic acid) fibrous mesh scaffolds
Author(s) -
Wan Ying,
Cao Xiaoying,
Wu Quan,
Zhang Shengmin,
Wang Sheng
Publication year - 2008
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.980
Subject(s) - materials science , ultimate tensile strength , chitosan , spinning , lactic acid , composite material , compressive strength , modulus , scaffold , elastic modulus , young's modulus , chemical engineering , biomedical engineering , medicine , biology , bacteria , engineering , genetics
DL ‐lactic acid was grafted onto chitosan to produce poly(chitosan‐ g ‐ DL ‐lactic acid)(PCLA) without using a catalyst. These PCLAs were then spun into filaments and further fabricated into fibrous mesh scaffolds using an improved wet‐spinning technique. The diameter of filaments in different scaffolds could vary from a few micrometers to several tens of micrometers. The scaffolds exhibited various pore sizes ranging from about 20 µm to more than 200 µm and different porosities up to 80%. The several main processing conditions were optimized for obtaining the desired scaffolds with well‐controlled structures. The tensile and compressive mechanical properties of the mesh scaffolds in both dry and hydrated states were mainly examined. Significantly improved tensile strength and modulus, enhanced compressive modulus, and stress as well as the dimensional stability for these mesh scaffolds in their hydrated state were observed. Copyright © 2007 John Wiley & Sons, Ltd.