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A new copolymer membrane cured by 2‐hydroxy‐3‐phenoxypropylacrylate, 4‐hydroxybutyl acrylate, and isobutyl methacrylate controlled clonidine linear release in the transdermal drug delivery system
Author(s) -
Zhan Xiaoping,
Chen Sijing,
Tang Guochun,
Mao Zhenmin
Publication year - 2007
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.901
Subject(s) - transdermal , copolymer , acrylate , materials science , membrane , methacrylate , monomer , polymer chemistry , clonidine , permeation , butyl acrylate , methyl methacrylate , drug delivery , nuclear chemistry , chemistry , polymer , composite material , pharmacology , nanotechnology , medicine , biochemistry , endocrinology
The main objective of this present study was to synthesize a new type of copolymer membrane that presented a linear release property in clonidine transdermal drug delivery system. Three monomers, 2‐hydroxy‐3‐phenoxypropylacrylate, 4‐hydroxybutyl acrylate, and isobutyl methacrylate were treated under strong power UV radiation to prepare a new type of copolymer membrane. The effects of monomers' ratios, membrane thickness, and clonidine concentration on the permeation rates were investigated. It was discovered that the membrane controlled clonidine near zero‐order release. Furthermore, the membrane was characterized by FTIR, DSC, and SEM. Copyright © 2007 John Wiley & Sons, Ltd.