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Effect of immobilization with chondroitin‐6‐sulfate and grafting with chitosan on fibroblast and antibacterial activity of polyester fibers
Author(s) -
Jou ChiHsiung,
Lee JuiSheng,
Chou WenLi,
Yu DaGuang,
Yang MingChien
Publication year - 2005
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.658
Subject(s) - grafting , chitosan , antibacterial activity , polyester , nuclear chemistry , fibroblast , chondroitin sulfate , materials science , polymer chemistry , acrylic acid , polymer , chemistry , bacteria , organic chemistry , biochemistry , glycosaminoglycan , copolymer , composite material , biology , in vitro , genetics
Poly(ethylene terephthalate) (PET) fibers were treated with 60 Co‐ γ ‐ray and grafted with acrylic acid (AA), and further grafted with chitosan (CS) via esterification. Afterwards these CS‐grafted fibers were then immobilized with chondroitin‐6‐sulfate (ChS). The blood compatibility of PET was reduced by grafting with CS, while improved by immobilizing with ChS. The antibacterial activity of CS against Staphylococcus aureus , and Pseudomonas aeruginosa was retained after ChS‐immobilization. After immobilizing ChS, the L929 fibroblasts cell proliferation was higher than CS‐grafting PET fibers. The results indicate that by grafting with CS and immobilizing with ChS, PET fibers can not only exhibit antibacterial activity, but also improve the cell proliferation for fibroblast activity. Copyright © 2005 John Wiley & Sons, Ltd.