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Synthesis and characterization of pendant carboxylic acid functional poly(lactic acid) and poly(lactic acid‐co‐glycolic acid) and their drug release behaviors
Author(s) -
KayamanApohan N.,
Akdemir Z. S.
Publication year - 2005
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.656
Subject(s) - glycolic acid , lactic acid , gel permeation chromatography , polymer , polyester , materials science , lactide , polymer chemistry , polymerization , copolymer , scanning electron microscope , biodegradable polymer , hydroxymethyl , polylactic acid , solubility , drug delivery , nuclear chemistry , organic chemistry , chemistry , nanotechnology , genetics , bacteria , composite material , biology
Abstract The carboxylic acid functionalized biodegradable aliphatic polyesters were prepared by ring‐opening polymerization of L ‐lactide and glycolide with 2,2′‐bis(hydroxymethyl propionic acid) (HMPA) as an initiator. The polymers were characterized by FT‐IR, 1 H‐NMR and gel permeation chromatography (GPC). Molecular weights of homopolymers and copolymers ranged from 0.28 × 10 4 to 11 × 10 4 and decreased with increasing weight fraction of HMPA in the feed. Moreover by changing the HMPA content, the solubility and degradation behavior of resulting polymers could be varied. Environmental scanning electron microscopy (ESEM) studies revealed that the microspheres were spherical in shape and had a smooth surface texture. For the investigation of drug release behavior of biopolymers, Lidocain was used as a model ionic drug. It was observed that an increase in drug loading reduces the encapsulation efficiency. After the initial burst, the release rate of the drug increased with time, with most of the drug released within 15 days. Copyright © 2005 John Wiley & Sons, Ltd.