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Chirality of proteinoid nanoparticles made of lysine and phenylalanine
Author(s) -
Lugasi Liroy,
Otis Gil,
Oliel Matan,
Margel Shlomo,
Mastai Yitzhak
Publication year - 2022
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.5667
Subject(s) - enantioselective synthesis , isothermal titration calorimetry , phenylalanine , chirality (physics) , adsorption , circular dichroism , enantiomer , lysine , amino acid , stereochemistry , materials science , organic chemistry , chemistry , catalysis , biochemistry , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
Proteinoid nanoparticles composed of l ‐lysine and l ‐phenylalanine were prepared and showed enantioselective adsorption of l ‐amino acids at various pH values, emphasizing the chiral nature of the particles. The adsorption was examined using circular dichroism, isothermal titration calorimetry and ζ‐potential measurements. Positively charged ammonium moieties on the proteinoid surface are most likely responsible for the enantioselective adsorption owing to their chirality which originates from l ‐lysine. Accordingly, a higher enantiomeric excess was found for amino acids such as alanine with a more negative charge.