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Synthesis of a low thrombogenic heart valve coating with horseradish peroxidase
Author(s) -
Benson Adrienne M.,
Omrane Kamel,
Graves Erin M.,
Haas Amy L.,
Bryant Erica,
Mandalaywala Monisha,
Mueller Anja
Publication year - 2005
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.561
Subject(s) - horseradish peroxidase , coating , adhesion , materials science , covalent bond , polymer , platelet adhesion , biomedical engineering , polymer chemistry , nanotechnology , chemistry , organic chemistry , composite material , enzyme , medicine
Cardiovascular implants like artificial heart valves are made out of a variety of materials to allow for adequate mechanical properties and mechanical movement. All of these materials have different adhesion properties towards blood proteins but all still induce blood coagulation. This article describes the design and enzymatic synthesis of a heart valve coating that would adhere to different materials as well as prevent adhesion of proteins to the surface to prevent blood coagulation. It consists of two covalently linked hyperbranched polymer thin films: one that provides strong adhesion to the surface in question and another that prevents adhesion of blood proteins. The synthesis of hyperbranched polyresorcinol and linear polyhydroquinone is presented for the thin film that adheres to the artificial heart valve. The synthesis of polyglycerol and poly(glucuronic acid) is presented for the anti‐thrombogenic thin film. The polymers are synthesized by horseradish peroxidase in water or buffer. Some of these syntheses do not use any other oxidant than oxygen, and the mechanism of these reactions is currently under investigation. The syntheses still need to be characterized in more detail and optimized. These polymers will be covalently linked to form the heart valve coating. Copyright © 2005 John Wiley & Sons, Ltd.