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Poly(glycerol citrate)‐polylactide nonwovens toward tissue engineering applications
Author(s) -
Wrzecionek Michał,
Bandzerewicz Aleksandra,
Dutkowska Ewa,
Dulnik Judyta,
Denis Piotr,
GadomskaGajadhur Agnieszka
Publication year - 2021
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.5407
Subject(s) - glycerol , citric acid , polyester , materials science , electrospinning , tissue engineering , chemical engineering , covalent bond , porosity , reagent , polymer science , composite material , polymer , organic chemistry , biomedical engineering , chemistry , medicine , engineering
In 2002, Robert Langer proposed that new polyester for tissue engineering should have good mechanical properties followed by: covalent bonding (as crosslinking) and hydrogen‐bonding interactions; and should be elastic like rubber materials due to three‐dimensional network structure. Considering these hypotheses, a polyester made of glycerol and citric acid was designed in this work. Poly(glycerol citrate) should be attractive for tissue engineering because both glycerol and citric acid, taking part in natural human metabolic pathways; and due to the reactant's functionality, 3D networks should be produced easily. Moreover, the reagents are cheap, available, and often used in the food and pharmaceutical industries. In this work, poly(glycerol citrate) was synthesized and then used with PLA for creating porous nonwovens by electrospinning. Produced materials were tested for possible application in the field of tissue engineering. The obtained materials have properties similar to collagen fibers, but still, require refinement for medical applications.