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Synthesis of PEGylated superparamagnetic dendrimers and their applications as a drug delivery system
Author(s) -
Parham Negin,
Ahmad Panahi Homayon,
Feizbakhsh Alireza,
Moniri Elham
Publication year - 2021
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.5194
Subject(s) - materials science , dynamic light scattering , thermogravimetric analysis , superparamagnetism , nanocomposite , polyethylene glycol , fourier transform infrared spectroscopy , drug delivery , dendrimer , chemical engineering , transmission electron microscopy , nanotechnology , nanoparticle , nuclear chemistry , polymer chemistry , chemistry , magnetization , physics , quantum mechanics , magnetic field , engineering
In this work, five generations of dendrimers were grafted to magnetic nanoparticles; then, polyethylene glycol was used to modify dendrimers. The structure and morphology are systemically studied by Fourier transform infrared spectroscopy (FT‐IR), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA), energy‐dispersive X‐ray spectrometer (EDS), transmission electron microscopy (TEM), field emission scanning electron microscopy (FE‐SEM), and dynamic light scattering (DLS). Batch experiments were performed to investigate the effect of solution pH and temperature. The possibility of using the nanocomposite for adsorption and release of the rivaroxaban was studied which indicated that the synthesis nanocomposite exhibited a much improved performance which allowed the 100% of the entrapped molecules to be slowly released during a much longer period time (35 h) in human blood environment, and drug release was Fickian‐diffusion‐controlled. The results revealed that the synthesized nanocomposite has an acceptable performance in drug release and will be developed for any usage of drug delivery.