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Study of highly porous poly‐ l ‐lactide‐based composites with chitosan and collagen
Author(s) -
Antipova Christina G.,
Lukanina Ksenia I.,
Krasheninnikov Sergey V.,
Malakhov Sergey N.,
Kamyshinsky Roman A.,
Grigoriev Timofei E.,
Chvalun Sergey N.
Publication year - 2021
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.5136
Subject(s) - chitosan , materials science , biomaterial , composite material , electrospinning , tissue engineering , porosity , nanofiber , polylactic acid , wetting , polymer , scaffold , chemical engineering , biomedical engineering , nanotechnology , medicine , engineering
Increased interest in the field of tissue engineering promotes the development of biomaterial design. Aspiration to reconstruct native extracellular matrix architecture (ECM) expands the number of applying approaches in polymer scaffold development. In the present work, we proposed a combination of electrospinning and lyophilization techniques to produce materials with ECM‐like morphology based on poly‐ l ‐lactide fiber matrix with natural bio‐adequate fillers (collagen and chitosan). Morphology, mechanical properties, and hydrophilicity of the developed biomaterials were studied. The introduction of the collagen filler enhanced the strength and Young's modulus of the composites by 190% and 80%. The same characteristics of the chitosan‐containing material were increased by 430% and 340%, respectively. It exceeded the collagen ones, which was caused by the better chitosan penetration into the fiber matrix and, as a result, the percolation network formation. The possibility of material wettability improving was shown.