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Original method of imprinting pores in scaffolds for tissue engineering
Author(s) -
GadomskaGajadhur Agnieszka,
Kruk Aleksandra,
Ruśkowski Paweł,
Sajkiewicz Paweł,
Dulnik Judyta,
Chwojnowski Andrzej
Publication year - 2021
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.5091
Subject(s) - materials science , gelatin , polyvinylpyrrolidone , tissue engineering , poloxamer , chemical engineering , biomedical engineering , polymer chemistry , composite material , polymer , copolymer , chemistry , organic chemistry , engineering , medicine
Results of the preparation of biodegradable porous scaffolds using an original modification of a wet phase inversion method were presented. Influence of gelatin non‐woven as a non‐classic pore precursor and polyvinylpyrrolidone, Pluronic as classic pore precursors on the structure of obtained scaffolds was analyzed. It was shown that the addition of gelatin non‐wovens enables the preparation of scaffolds, which allow for the growth of cells (size, distribution, and shape of pores). Mechanical properties of the obtained cell scaffolds were determined. The influence of pore precursors on mass absorption of scaffolds against isopropanol and plasma was investigated. Interaction of scaffolds with a T‐lymphocyte line (Jurkat) and with fibroblasts (L929) was investigated. Obtained scaffolds are not cytotoxic and can be used as implants, for example, the regeneration of cartilage tissue.