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Tragacanth gum‐based pH ‐responsive magnetic hydrogels for “smart” chemo/hyperthermia therapy of solid tumors
Author(s) -
Sayadnia Soughand,
Arkan Elham,
JahanbanEsfahlan Rana,
Sayadnia Sahar,
Jaymand Mehdi
Publication year - 2021
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.5082
Subject(s) - materials science , self healing hydrogels , hela , drug delivery , nuclear chemistry , doxorubicin hydrochloride , biocompatibility , fourier transform infrared spectroscopy , tragacanth , hyperthermia , nanoparticle , transmission electron microscopy , mtt assay , biomedical engineering , nanotechnology , chemical engineering , doxorubicin , polymer chemistry , chemistry , medicine , biochemistry , apoptosis , in vitro , surgery , chemotherapy , engineering , food science , metallurgy
The drug delivery performances of pH‐responsive magnetic hydrogels (MHs) composed of tragacanth gum (TG), poly(acrylic acid) (PAA), and Fe 3 O 4 nanoparticles (NPs) were investigated in terms of physicochemical as well as biological features. The fabricated drug delivery systems (DDSs) were analyzed using Fourier transform infrared spectroscopy, X‐ray diffraction, vibrating sample magnetometer, scanning electron microscopy, and transmission electron microscopy. The synthesized MHs were loaded with doxorubicin hydrochloride (Dox) as a universal model anti‐cancer drug. The MHs showed excellent Dox loading and encapsulation efficiencies, mainly due to strong hydrogen bonding and electrostatic interaction between the drug and polymeric matrix, as well as porous micro‐structures of the fabricated MHs. The drug‐loaded MHs showed negligible drug release values in physiological condition. In contrast, in cancerous condition (pH 5.0), both MHs exhibited highest drug release values that qualified them as “smart” DDSs. The cytocompatibilities of the MHs as well as the cytotoxicity of the Dox‐loaded MHs were investigated against human epidermoid‐like carcinoma (Hela) cells through MTT assay. In addition, hyperthermia therapy induced by Fe 3 O 4 NPs was applied to locally raise temperature inside the Hela cells at 45 ± 3°C to promote cell death. As a result, the Dox‐loaded MHs can be considered as potential DDSs for chemo/hyperthermia therapy of solid tumors.