Premium
Investigation of drug release from thermo‐ and pH‐sensitive poly( N ‐isopropylacrylamide/itaconic acid) copolymeric hydrogels
Author(s) -
Taşdelen B.,
KayamanApohan N.,
Güven O.,
Baysal B. M.
Publication year - 2004
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.505
Subject(s) - itaconic acid , self healing hydrogels , comonomer , poly(n isopropylacrylamide) , swelling , materials science , drug delivery , polymer chemistry , methylene blue , nuclear chemistry , chemical engineering , copolymer , chemistry , organic chemistry , nanotechnology , polymer , composite material , engineering , catalysis , photocatalysis
N ‐Isopropylacrylamide/itaconic acid copolymeric hydrogels were prepared by irradiation of the ternary mixtures of N ‐isopropylacrylamide/itaconic acid/water by γ ‐rays at ambient temperature. The dependence of swelling properties and phase transitions on the comonomer concentration and temperature were investigated. The hydrogels showed both temperature and pH responses. The effect of comonomer concentration on the uptake and release behavior of the hydrogels was studied. Methylene blue (MB) was used as a model drug for the investigation of drug uptake and release behavior of the hydrogels. The release studies showed that the basic parameters affecting the drug release behavior of the hydrogels were pH and temperature of the solution. Copyright © 2004 John Wiley & Sons, Ltd.