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Nonleaching antimicrobial poly(vinyl alcohol)/polyhexamethylene guanidine hydrochloride hydrogels reinforced by hydrogen bond
Author(s) -
Gong Wuling,
Wei Dafu,
Zhang Shaotian,
Jiang Yachao,
Ye Jingyun,
Zheng Anna,
Guan Yong
Publication year - 2020
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.5048
Subject(s) - self healing hydrogels , vinyl alcohol , antimicrobial , materials science , ultimate tensile strength , compounding , polymer chemistry , polymer , composite material , nuclear chemistry , organic chemistry , chemistry
Antimicrobial poly(vinyl alcohol) (PVA) hydrogels attracted much attentions in the last decade. In this work, a novel antimicrobial PVA hydrogel was prepared through compounding PVA with polyhexamethylene guanidine hydrochloride (PHMG) and freezing‐thawing method. These composite hydrogels behaved above 99.9% of antimicrobial rates against both Escherichia coli and Staphylococcus aureus even at 0.003 wt% of PHMG, and the nonleaching characteristic of PHMG as well as long‐acting antimicrobial activities. The PVA/0.100 wt% PHMG hydrogel had 120% higher tensile strength than pure PVA hydrogel, and its water vapor transmission rate was 4530 ± 245 g/m 2 /d, which was at an optimal range for injured skin (279‐5138 g/m 2 /d). This work provides a simple approach to develop nonleaching antimicrobial PVA hydrogels with extremely few PHMG for wound dressing and other potential applications in biomedical field.