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Development of pH ‐responsive cyclodextrin nanoparticles for tumor‐specific photodynamic therapy
Author(s) -
Yoon Seonyoung,
Noh Gwang Jin,
Youn Yu Seok,
Oh Kyung Taek,
Lee Eun Seong
Publication year - 2020
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.5047
Subject(s) - cyclodextrin , ethylene glycol , peg ratio , photodynamic therapy , materials science , nanoparticle , drug delivery , chemistry , biophysics , combinatorial chemistry , organic chemistry , nanotechnology , finance , economics , biology
In this study, we report pH‐responsive porous polysaccharide nanoparticles (NPs) for tumor‐specific photodynamic therapy. Herein, γ‐cyclodextrin (γCD) conjugated with 3‐(diethylamino)propylamine (DEAP, as a pH‐responsive moiety) and poly(ethylene glycol) (PEG) was used to fabricate γCD‐(DEAP/PEG) NPs using a self‐assembling process with γCD and PEG as a hydrophilic segment and DEAP as a hydrophobic segment. These NPs contain rich pore channels, allowing for the facile encapsulation of chlorin e6 (Ce6, as a model drug) via host‐guest supramolecular interactions. Furthermore, the DEAP moieties (pK b ~ 7.0) in the γCD‐(DEAP/PEG) NPs could be protonated at weakly acidic pH (pH 6.8) in a tumor environment. This event resulted in the rapid structural destabilization of the host γCD‐(DEAP/PEG) NPs owing to the protonated DEAP moieties, thereby leading to the extensive release of the phototoxic Ce6 guest. Consequently, the Ce6‐loaded γCD‐(DEAP/PEG) NPs exhibited a significant inhibition of MDA‐MB‐231 tumor cell growth under light irradiation, demonstrating their potential as a tumor‐specific photosensitizing drug carrier.