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Biodegradable super porous inulin cryogels as potential drug carrier
Author(s) -
Ari Betul,
Sahiner Nurettin
Publication year - 2020
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.5014
Subject(s) - inulin , swelling , hydrolysis , phosphate buffered saline , hemolysis , materials science , nuclear chemistry , chemistry , chromatography , biochemistry , medicine , composite material , immunology
Here, chemically crosslinked super porous inulin cryogels were synthesized by the cryogelation method using divinyl sulfone (DVS) at various mol ratios of 75% to 150% inulin repeating units. Inulin cryogel prepared at 75 mol% DVS crosslinking showed a maximum swelling capacity of 1842 ± 159% in phosphate buffer saline (PBS, pH 7.4). The hydrolytic degradation of inulin cryogels prepared at different ratios were investigated at 37.5 °Cat pH 1, 7.4, and 9. Depending on the degree of crosslinking, it was found that inulin cryogels were completely degraded in 1 to 6 days at pH 1, and the degradation continued at pH 7.4 and 9 for up to 21 days. Inulin cryogel with 75 mol% crosslinker had 61% ± 7% and 45% ± 2% weight losses at pH 7.4 and pH 9, respectively, at end of 21 days. Also, 75% crosslinked inulin cryogel was conjugated with amoxicillin trihydrate (AMX) drug and released 65.15 ± 5.35 mg/g of AMX at pH 1 at end of 24 hours. At pH 7.4 and 9, the AMX released amount were determined as 64.83 ± 6.19 and 55.57 ± 4.00 mg/g, respectively, in 120 hours. Furthermore, inulin cryogels were determined to be blood compatible materials via hemolytic tests with hemolysis ratio of 1.08% ± 0.14% and a blood clotting index of 80.67% ± 1.86%.