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Recent progress in the development of immobilized penicillin G acylase for chemical and industrial applications: A mini‐review
Author(s) -
Li Ke,
Mohammed Monier Alhadi Abdelrahman,
Zhou Yongshan,
Tu Hongyi,
Zhang Jiachen,
Liu Chunli,
Chen Zhenbin,
Burns Robert,
Hu Dongdong,
Ruso Juan M.,
Tang Zhenghua,
Liu Zhen
Publication year - 2020
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.4791
Subject(s) - penicillin , immobilized enzyme , catalysis , materials science , penicillin amidase , biochemical engineering , combinatorial chemistry , chemistry , enzyme , antibiotics , organic chemistry , biochemistry , engineering
Immobilized penicillin G acylase (PGA) as an important industrial catalyst can catalyze penicillin G potassium (PG) to 6‐aminopenicillanic acid (6‐APA). 6‐APA is an important intermediate for semisynthetic penicillin drugs, which occupies a huge market space in the anti‐inflammatory field; as a result, immobilized PGA occupies a huge market space in the pharmaceutical field. However, at present, there are different degrees of defects in the preparation and production process of immobilized PGAs on the market because of the huge demand; therefore, the performance of immobilized PGA and its productivity will bring huge economic benefits to enterprises. Therefore, research on immobilized PGA has always been a focus. This review first introduces the source, classification, structure, and catalytic mechanism of PGA and then studies the development of immobilization methods, immobilized carriers, reaction media, enzyme activity regeneration, and reactors of immobilized PGA in recent years.