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Paclitaxel loaded poly (DL lactic acid co castor oil) 60:40 with poloxamer‐F68 rod shape cylindrical nanoparticle preparation and in vitro cytotoxicity studies
Author(s) -
SreeHarsha Nagaraja,
Hiremath Jagadeesh G.,
Aitha Rajesh Kumar,
Domb Abraham J.,
AlDhubiab Bandar E.,
Ramnarayanan Chandramouli,
Alzahrani Abdullah Mossa,
Venugopala Katharigatta N.,
Akrawi Sabah H.,
Attimarad Mahesh,
Nair Anroop B.
Publication year - 2019
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.4719
Subject(s) - materials science , differential scanning calorimetry , castor oil , nanoparticle , crystallinity , fourier transform infrared spectroscopy , lactic acid , nuclear chemistry , poloxamer , ricinoleic acid , chemical engineering , drug delivery , polymer , nanotechnology , composite material , organic chemistry , chemistry , copolymer , physics , genetics , biology , bacteria , engineering , thermodynamics
This research presents a thin‐film hydration‐solvent evaporation method to formulate the paclitaxel loaded poly (DL lactic acid co castor oil) 4:6 with poloxamer‐F68 cylindrical shape nanoparticles. The particles were less than 250 nanometers (nm) in size, with an average width of 60 nm and an average length of 100 nm. The percent yield, encapsulation efficiency (EE), and percent drug loading (DL) were detected. This approach produces drug loading values between 5% and 20% w/w. X‐ray powder diffraction (XRD) identified the physicochemical properties of nanoparticles differential scanning calorimetry (DSC) and Fourier‐transform infrared spectroscopy (FTIR). The investigation shows that the drug is molecularly dispersed in polymers or given in an amorphous or semicrystalline state. Horizontal water bath shaker technology considered the in vitro release of PTX loaded nanoparticles under sink conditions. Poly (DL lactic acid co castor oil) 4:6 nanoparticles exhibited a sustained release analysis. At the end of 30 hours, the percent cumulative drug release from the formulations was between 74.52% and 92.87% for F1 and F4. In vitro cytotoxicity assays indicate that PTX having p (DLLA:CO60:40) nanoparticles have a higher cytotoxic effect on MCF‐7/ADR.