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Alginate hydrogels incorporating neomycin or propolis as potential dressings for diabetic ulcers: Structure, swelling, and antimicrobial barrier properties
Author(s) -
Candido Juliana Dumard Carracena,
Conceição Natália Alves,
Moreira Ana Paula Duarte,
Calçada Luís Américo,
Araújo Leonardo Sales,
Santos Robson Araújo,
Middea Antonieta,
Luchese Rosa,
Prudencio Edlene Ribeiro,
Castro Rosane Nora,
McGuinness Garrett Brian,
Oliveira Renata Nunes
Publication year - 2019
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.4679
Subject(s) - self healing hydrogels , swelling , materials science , antimicrobial , neomycin , microparticle , penetration (warfare) , drug delivery , propolis , wound dressing , biomedical engineering , composite material , chemical engineering , nanotechnology , microbiology and biotechnology , polymer chemistry , chemistry , medicine , antibiotics , food science , organic chemistry , operations research , engineering , biology
Alginate hydrogels have many attractive characteristics for potential use as wound dressing materials. However, they are not considered to possess any intrinsic activity against microbial infection, often present in neuropathic wounds. To overcome this, the effect of incorporating neomycin or propolis in alginate hydrogels was investigated, both by direct blending alone and also by further addition of loaded alginate microparticles prepared by the extrusion dripping method. The morphological, microstructural, thermal, mechanical, and swelling properties of each film were evaluated, as well as particle size distribution and antimicrobial penetration analysis. Microparticle size was considered suitable for drug delivery applications and incorporation in hydrogel films. The presence of neomycin and propolis, in both blended and microparticle form, interfered with film properties leading to hydrogels with different characteristics. All samples showed swelling degrees up to 100% and mechanical and thermal properties suitable for application as wound dressings. In addition, all samples acted as barriers to microbial penetration.