Premium
A modified polyvinylchloride surface with antibacterial and antifouling functions
Author(s) -
Almousa Rashed,
Wen Xin,
Na Sungsoo,
Anderson Gregory,
Xie Dong
Publication year - 2019
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.4554
Subject(s) - biofouling , adhesion , antibacterial activity , materials science , bacteria , covalent bond , cell adhesion , surface modification , bacterial growth , polymer , pseudomonas aeruginosa , bacterial cell structure , staphylococcus aureus , coating , polymer chemistry , chemistry , nanotechnology , organic chemistry , biochemistry , biology , composite material , membrane , genetics
Surfaces with antibacterial and hydrophilic properties are very attractive to cardiovascular applications. The objective of this study was to synthesize and immobilize a novel antibacterial and hydrophilic polymer onto surface of polyvinylchloride via an effective and mild surface coating technique. The surface coated with a terpolymer constructed with N ‐vinylpyrrolidone, 3,4‐dichloro‐5‐hydroxy‐2(5 H )‐furanone derivative, and succinimide residue was evaluated with cell adhesion, bacterial adhesion, and bacterial viability. 3T3 mouse fibroblast cells and two bacteria species were used to evaluate surface adhesion and antibacterial activity. Results showed that the polymer‐modified polyvinylchloride surface exhibited not only significantly decreased 3T3 fibroblast cell adhesion with a 66% to 87% reduction but also significantly decreased bacterial adhesion with 69% to 87% and 52% to 74% reduction of Pseudomonas aeruginosa and Staphylococcus aureus attachment, respectively, as compared with original polyvinylchloride. Furthermore, the modified polyvinylchloride surfaces exhibited significant antibacterial functions by inhibiting bacterial growth (75%‐84% and 78–94% inhibition of P aeruginosa and S aureus , respectively, as compared to original polyvinylchloride) and killing bacteria. These results demonstrate that covalent polymer attachment conferred antifouling and antibacterial properties to the polyvinylchloride surface.