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Ile‐Lys‐Val‐ala‐Val (IKVAV) peptide for neuronal tissue engineering
Author(s) -
Patel Rajkumar,
Santhosh Mallesh,
Dash Jatis Kumar,
Karpoormath Rajshekhar,
Jha Amitabh,
Kwak Jeonghun,
Patel Madhumita,
Kim Jong Hak
Publication year - 2019
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.4442
Subject(s) - scaffold , tissue engineering , extracellular matrix , neurite , peptide , in vivo , microbiology and biotechnology , laminin , cell , materials science , biophysics , in vitro , chemistry , biology , biochemistry , biomedical engineering , medicine
Despite the great advances in microsurgery, some neural injuries cannot be treated surgically. Stem cell therapy is a potential approach for treating neuroinjuries and neurodegenerative disease. Researchers have developed various bioactive scaffolds for tissue engineering, exhibiting enhanced cell viability, attachment, migration, neurite elongation, and neuronal differentiation, with the aim of developing functional tissue grafts that can be incorporated in vivo. Facilitating the appropriate interactions between the cells and extracellular matrix is crucial in scaffold design. Modification of scaffolds with biofunctional motifs such as growth factors, drugs, or peptides can improve this interaction. In this review, we focus on the laminin‐derived Ile‐Lys‐Val‐Ala‐Val peptide as a biofunctional epitope for neuronal tissue engineering. Inclusion of this bioactive peptide within a scaffold is known to enhance cell adhesion as well as neuronal differentiation in both 2‐dimensional and 3‐dimensional environments. The in vivo application of this peptide is also briefly described.