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Formulation characterization and in vitro evaluation of acacia gum–calcium alginate beads for oral drug delivery systems
Author(s) -
Benfattoum Kahina,
Haddadine Nabila,
Bouslah Naima,
Benaboura Ahmed,
Maincent Philippe,
Barillé Régis,
SapinMinet Anne,
ElShall M. Samy
Publication year - 2018
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.4199
Subject(s) - swelling , materials science , gum acacia , drug delivery , differential scanning calorimetry , factorial experiment , calcium , controlled release , nuclear chemistry , calcium alginate , glucuronic acid , chitosan , chromatography , chemical engineering , chemistry , polysaccharide , organic chemistry , composite material , nanotechnology , food science , physics , statistics , mathematics , engineering , metallurgy , thermodynamics
In the present work, new matrix bead formulations based on linear and branched polysaccharides have been developed using an ionic gelation technique, and their potential use as oral drug carriers has been evaluated. Using calcium chloride as a cross‐linking agent and sodium diclofenac (SD), as a model drug, acacia gum–calcium alginate matrix beads were formulated. The response surface methodology based on 3 2 factorial design was used as a statistical method to evaluate and optimize the effects of the biopolymers‐blend ratio and the concentration of calcium chloride on the particle size (mm), density (g/cm 3 ), drug encapsulation efficiency (%), and the cumulative drug release after 8 hours (R 8h ,%). The optimized beads with the highest drug encapsulation efficiency were examined for a drug‐excipients compatibility by powder X‐ray diffraction, differential scanning calorimetry, thermo‐gravimetric analysis, and Fourier transform‐infrared spectroscopy analyses. The swelling and degradation of the matrix beads were found to be influenced by the pH of medium. Higher degrees of swelling were observed in intestinal pH than in stomach pH. Accordingly, the drug release study showed that the amount of SD released from the acacia gum–calcium alginate beads was higher in intestinal pH than in stomach pH. Therefore, the in vitro drug release from the SD‐loaded beads appears to follow the controlled‐release (Hixson‐Crowell) pattern involving a case‐2 transport mechanism operated by swelling and relaxation of the polymeric blend matrix.