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Synthesis of inositol‐based star polymers through low ppm ATRP methods
Author(s) -
Chmielarz Paweł
Publication year - 2017
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.4065
Subject(s) - atom transfer radical polymerization , polymer chemistry , ethylene glycol , methacrylate , materials science , polymer , methyl methacrylate , ether , polymerization , chemistry , organic chemistry
The vitamin B 8 ‐based macroinitiator with six 2‐bromoisobutyric initiating sites was prepared for the first time by the transesterification reaction of meso ‐inositol with 2‐bromoisobutyryl bromide. A series of six‐armed (co)polymers, containing hydrophilic poly(di(ethylene glycol) methyl ether methacrylate) and amphiphilic poly(di(ethylene glycol) methyl ether methacrylate)‐ block ‐poly(methyl methacrylate) as the arms and meso ‐inositol as the core, were obtained by low ppm atom transfer radical polymerization (ATRP) methods, utilizing 30 ppm of catalyst complex. Under Fe 0 ‐mediated supplemental activators and reducing agents ATRP, Cu 0 ‐mediated supplemental activators and reducing agents ATRP, Ag 0 ‐mediated activators regenerated by electron transfer ATRP, and simplified electrochemically mediated ATRP conditions, polymerization proceeded on to high conversion while maintaining low dispersity ( Đ = 1.05–1.16) giving well‐defined six‐armed star (co)polymers. 1 H NMR spectral results confirm the formation of new star‐shaped block (co)polymers. The absence of intermolecular coupling reactions during synthesis was confirmed by gel permeation chromatography analyses of the side chains of received star (co)polymers. These vitamin B 8 ‐based star (co)polymers may find biomedical applications as thermo‐sensitive drug delivery systems, biosensors, and tissue engineering solutions. Copyright © 2017 John Wiley & Sons, Ltd.