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Oxygen‐releasing poly(trimethylene carbonate) microspheres for tissue engineering applications
Author(s) -
Steg Hilde,
Buizer Arina T,
Woudstra Willem,
Veldhuizen Albert G,
Bulstra Sjoerd K,
Grijpma Dirk W,
Kuijer Roel
Publication year - 2017
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3919
Subject(s) - materials science , trimethylene carbonate , carbonate , microsphere , oxygen , tissue engineering , chemical engineering , biomedical engineering , composite material , polymer , metallurgy , organic chemistry , copolymer , medicine , engineering , chemistry
The introduction of tissue engineering therapies for the repair of bone defects has been limited by poor survival of implanted cells. Because of the absence of a vascular network, the cells in a cell‐scaffold construct are not adequately supplied with oxygen and nutrients. Thus far, all but one strategies to solve this problem have failed. Fortunately, oxygen‐delivering biomaterials have shown promising results. In this study, composite microspheres comprising a poly(trimethylene carbonate) matrix and calcium peroxide particles (PTMC/CaO 2 ) were prepared and assessed for their oxygen‐delivering capacity and potential cytotoxicity. PTMC/CaO 2 composite microspheres were shown to release oxygen for several weeks. Oxygen release appeared to be dependent on the presence of cholesterol esterase in the medium. The microspheres were not cytotoxic and promoted mesenchymal stromal cell proliferation under hypoxic conditions in vitro . Copyright © 2016 John Wiley & Sons, Ltd.