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Injectable poly(ethylene glycol) hydrogels for sustained doxorubicin release
Author(s) -
Gao Lilong,
Sun Qiang,
Wang Ying,
Zhu Weipu,
Li Xiaojun,
Luo Qiaojie,
Li Xiaodong,
Shen Zhiquan
Publication year - 2017
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3852
Subject(s) - ethylene glycol , self healing hydrogels , doxorubicin hydrochloride , materials science , polymer chemistry , combinatorial chemistry , doxorubicin , chemistry , organic chemistry , medicine , surgery , chemotherapy
Water‐soluble poly(ethylene glycol) derivatives with multiple “clickable” mercapto groups or double bonds were facilely synthesized in a large scale by direct polycondensation of oligo(ethylene glycol) diol with mercaptosuccinic acid or maleic acid catalyzed by scandium trifluoromethanesulfonate under mild conditions. Injectable hydrogels containing doxorubicin hydrochloride (DOX · HCl) could be rapidly formed using these poly(ethylene glycol) derivatives as precursors via in situ thiol‐ene “click” reaction under physiological conditions without light, initiator, or metal catalyst. DOX · HCl could be sustained released from the hydrogels as a result of the hindrance of the three dimensional hydrogel network on the drug molecules, which makes this kind of DOX‐loaded hydrogels a promising candidate for localized tumor chemotherapy. Copyright © 2016 John Wiley & Sons, Ltd.