Injectable poly(ethylene glycol) hydrogels for sustained doxorubicin release | Zendy

Gao Lilong | Zendy; Sun Qiang | Zendy; Wang Ying | Zendy; Zhu Weipu | Zendy; Li Xiaojun | Zendy; Luo Qiaojie | Zendy; Li Xiaodong | Zendy; Shen Zhiquan | Zendy

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Injectable poly(ethylene glycol) hydrogels for sustained doxorubicin release

Author(s) -

Gao Lilong,

Sun Qiang,

Wang Ying,

Zhu Weipu,

Li Xiaojun,

Luo Qiaojie,

Li Xiaodong,

Shen Zhiquan

Publication year - 2017

Publication title -

polymers for advanced technologies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.61

H-Index - 90

eISSN - 1099-1581

pISSN - 1042-7147

DOI - 10.1002/pat.3852

Subject(s) - ethylene glycol , self healing hydrogels , doxorubicin hydrochloride , materials science , polymer chemistry , combinatorial chemistry , doxorubicin , chemistry , organic chemistry , medicine , surgery , chemotherapy

Water‐soluble poly(ethylene glycol) derivatives with multiple “clickable” mercapto groups or double bonds were facilely synthesized in a large scale by direct polycondensation of oligo(ethylene glycol) diol with mercaptosuccinic acid or maleic acid catalyzed by scandium trifluoromethanesulfonate under mild conditions. Injectable hydrogels containing doxorubicin hydrochloride (DOX · HCl) could be rapidly formed using these poly(ethylene glycol) derivatives as precursors via in situ thiol‐ene “click” reaction under physiological conditions without light, initiator, or metal catalyst. DOX · HCl could be sustained released from the hydrogels as a result of the hindrance of the three dimensional hydrogel network on the drug molecules, which makes this kind of DOX‐loaded hydrogels a promising candidate for localized tumor chemotherapy. Copyright © 2016 John Wiley & Sons, Ltd.

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