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Characterization and cytotoxicity studies of thiol‐modified polystyrene microbeads doped with [{Mo 6 X 8 }(NO 3 ) 6 ] 2– (X = Cl, Br, I)
Author(s) -
Vorotnikova Natalya A.,
Efremova Olga A.,
Tsygankova Alphiya R.,
Brylev Konstantin A.,
Edeleva Mariya V.,
Kurskaya Olga. G.,
Sutherland Andrew J.,
Shestopalov Alexandr M.,
Mironov Yuri V.,
Shestopalov Michael A.
Publication year - 2016
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3749
Subject(s) - luminescence , photoluminescence , polystyrene , materials science , quantum yield , doping , molybdenum , octahedron , nuclear chemistry , thiol , cytotoxicity , analytical chemistry (journal) , crystallography , crystal structure , chemistry , in vitro , optics , organic chemistry , fluorescence , optoelectronics , polymer , biochemistry , composite material , physics , metallurgy
Halide octahedral molybdenum clusters [{Mo 6 X 8 }L 6 ] n– possess luminescence properties that are highly promising for biological applications. These properties are rather dependent on the nature of both the inner ligands X (i.e. Cl, Br, or I) and the apical organic or inorganic ligands L. Herein, the luminescence properties and the toxicity of thiol‐modified polystyrene microbeads (PS‐SH) doped with [{Mo 6 X 8 }(NO 3 ) 6 ] 2– (X = Cl, Br, I) were studied and evaluated using human epidermoid larynx carcinoma (Hep2) cell cultures. According to our data, the photoluminescence quantum yield of {Mo 6 I 8 }@PS‐SH is significantly higher (0.04) than that of {Mo 6 Cl 8 }@PS‐SH (<0.005) and {Mo 6 Br 8 }@PS‐SH (<0.005). Treatment of Hep2 cells with {Mo 6 X 8 }@PS‐SH showed that all three types of doped microbeads had no significant effect on the viability and proliferation of the cells. Copyright © 2016 John Wiley & Sons, Ltd.