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Synthesis of a new nanoparticle system based on electrostatic alginate‐piperazine interactions
Author(s) -
Román José V.,
RodríguezRodríguez Jesús A.,
Valle Eva M. Martín,
Galán Miguel A.
Publication year - 2016
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3731
Subject(s) - nanoparticle , piperazine , materials science , nanotechnology , covalent bond , drug delivery , surface charge , molecule , electrostatic interaction , aqueous solution , combinatorial chemistry , organic chemistry , chemistry , chemical physics
Advanced drug delivery system development is very important for the cancer therapies. The fixing of specific targeting ligands onto biodegradable carriers can add specificity to the usual chemotherapeutical treatments that current chemotherapies lack of. This study describes the preparation of a new nanoparticle system based on electrostatic interactions between alginate and piperazine. Nanoparticles with a negative surface charge were prepared through the electrostatic interaction between alginate and piperazine under acid aqueous condition. This kind of interactions and materials has never been used before to produce nanoparticles. This nanoparticle system has been designed to be used as a carrier where superficial carboxylate groups are the binding site for different kind of molecules, for example, proteins and organic molecules. Afterwards, surface engineering was performed on the nanoparticles produced; cisplatin and epidermal growth factor (EGF) were covalently linked on the surface of the nanoparticle using reagents by carbodiimide chemistry to give a covalent bond between EGF and nanoparticles and between cisplatin and nanoparticles. As a result, this study reports the development of a potential advanced drug delivery system, which in the future will enable clinical trials in animals and humans. Copyright © 2015 John Wiley & Sons, Ltd.