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Immuno‐compatibility of amphiphilic ABA triblock copolymer‐based hydrogel films for biomedical applications
Author(s) -
Görs Julia,
Roch Toralf,
Tartivel Lucile,
Behl Marc,
Ma Nan,
Lendlein Andreas
Publication year - 2015
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3676
Subject(s) - macromonomer , ethylene glycol , self healing hydrogels , copolymer , materials science , protein adsorption , methacrylate , polymer chemistry , polymer , amphiphile , cell encapsulation , chemical engineering , organic chemistry , chemistry , engineering , composite material
The protein adsorption and immuno‐compatibility of hydrogels largely influence the clinical outcome in biomedical application scenarios. In this study photo‐crosslinked 2‐isocyanate ethyl methacrylate–functionalized oligo(ethylene glycol)–oligo(propylene glycol)–oligo(ethylene glycol) (IEMA–OEG–OPG–OEG–IEMA)‐based polymer hydrogel films were explored with respect to endotoxin contaminations, intrinsic immuno‐modulatory features, and protein adsorption of human fibronectin as well as serum albumin. Therefore three different hydrogel films were prepared from aqueous solutions of dimethacrylated OEG–OPG–OEG triblock copolymers ( M n = 12,700 g mol −1 , 70 mol% OEG content) with varying wt% of the macromonomer (10 to 30%) resulting in polymeric networks, which differ in their crosslinking density and accordingly their physical properties. It could be shown that all three hydrogel film compositions do not cause complement and immune cell activation. The films were protein repellent, but reversible protein diffusion in and out of the hydrogel network, depending on the mesh size of the network, could be observed. In conclusion, the hydrogels can be considered as immuno‐compatible, which qualifies them for biomedical applications such as drug release systems. Copyright © 2015 John Wiley & Sons, Ltd.