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Synthesis and anti‐HIV activity of sulfated astragalus polysaccharide
Author(s) -
Liu GuoGuang,
Borjihan Gereltu,
Baigude Huricha,
Nakashima Hedeki,
Uryu Toshiyuki
Publication year - 2003
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.357
Subject(s) - sulfation , astragalus , polysaccharide , in vitro , traditional medicine , sulfur , human immunodeficiency virus (hiv) , chemical structure , chemistry , biology , biochemistry , organic chemistry , medicine , traditional chinese medicine , immunology , alternative medicine , pathology
Sulfated astragalus polysaccharide (sulfated astragalan, SA) was prepared by chemical modification of astragalus polysaccharide abstracted from an astragalus menbranceus used as a Mongolia herbal medicine. Anti‐HIV activity of SA was assayed in vitro and the results indicated that the SA showing high anti‐HIV activity and lower cytotoxity. Sulfation of astragalan was carried out by using sulfur trioxide‐pyridine complex in a mixture of dimethylsulfoxide (DMSO) to give sulfated astragalan with degree of substitution (DS) of 1.14–1.20 and a number average molecular weight ( M n ) of 1.27–1.46 × 10 4 . Copyright © 2003 John Wiley & Sons, Ltd.