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Preparation and characterization of poly(ethylene oxide)‐loaded hydroxypropyl‐ β ‐cyclodextrin nanofibers
Author(s) -
Hossain M. Forhad,
Gong R. Hugh,
Rigout Muriel
Publication year - 2015
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3552
Subject(s) - nanofiber , ethylene oxide , materials science , aqueous solution , fourier transform infrared spectroscopy , scanning electron microscope , cyclodextrin , fiber , nuclear chemistry , polymer , oxide , electrospinning , chemical engineering , polymer chemistry , composite material , copolymer , chromatography , chemistry , organic chemistry , engineering , metallurgy
Hydroxypropyl‐ β ‐cyclodextrin (HP‐ β ‐CD) is a modified β ‐cyclodextrin ( β ‐CD) derivative, which is toxicologically harmless to mammals and other animals. HP‐ β ‐CD is electrospun from an aqueous solution by blending with a non‐toxic, biocompatible, synthetic polymer poly(ethylene oxide) (PEO). Aqueous solutions containing different HP‐ β ‐CD/PEO blends (50:50–80:20) with variable concentrations (4 wt%–12 wt%) were used. Scanning electron microscope was used to investigate the morphology of the fibers, and Fourier transform infrared spectroscopy analysis confirmed the presence of HP‐ β ‐CD in the fiber. Uniform nanofibers with an average diameter of 264, 244, and 236 nm were obtained from 8 wt% solution of 50:50, 60:40, and 70:30 HP‐ β ‐CD/PEO, respectively. The average diameter of the fiber was decreased with increasing of HP‐ β ‐CD/PEO ratio. However, a higher proportion of HP‐ β ‐CD in the spinning solution increased beads in the fibers. The polymer concentration had no significant effect on the fiber diameter. The most uniform fibers with the narrowest diameter distribution were obtained from the 8 wt% of 50:50 solution. Copyright © 2015 John Wiley & Sons, Ltd.