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Castor oil–citric acid copolyester for tissue augmentation
Author(s) -
Ickowicz Diana E.,
HaimZada Moran,
Abbas Randa,
Touitou Dan,
Nyska Abraham,
Golovanevski Ludmila,
Weiniger Carolyn F.,
Katzhendler Jeoshua,
Domb Abraham J.
Publication year - 2014
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3345
Subject(s) - copolyester , castor oil , biocompatibility , polyester , polymer , materials science , copolymer , monomer , citric acid , hydrolytic degradation , in vivo , polymer chemistry , hydrolysis , nuclear chemistry , organic chemistry , chemistry , composite material , microbiology and biotechnology , metallurgy , biology
Biodegrable polyesters derived from hydroxy acids have a broad clinical use. The aim of the study was to synthesize polymer compositions based on citric acid and castor oil for use as soft tissue augmentation. Two polymers were synthesized, a branched viscous polyester with a monomer ratio of 93.5:6.5 w/w and an apparent molecular weight of 11,000 Da and a crosslinked semisolid polymer with a monomer ratio of 92.5:7.5 w/w. The branched polymer lost less than 10% of its weight during a 30‐day degradation study. In vivo biocompatibility study in rats showed 20% formulation weight loss 9 months post‐subcutaneous administration. These results were in accordance with the in vitro hydrolytic degradation of the polymer. The in vivo study revealed good tolerability of the copolymer. Copyright © 2014 John Wiley & Sons, Ltd.
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