Premium
Synthesis of amphiphilic dendronized polymers to study their self‐assembly and transport behavior
Author(s) -
Kumari Meena,
Singh Abhishek Kumar,
Kumar Shiv,
Achazi Katharina,
Gupta Shilpi,
Haag Rainer,
Sharma Sunil K.
Publication year - 2014
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3293
Subject(s) - amphiphile , candida antarctica , nile red , alkyl , copolymer , polymer , micelle , materials science , dendrimer , polymer chemistry , click chemistry , biocompatibility , aqueous solution , organic chemistry , lipase , chemistry , fluorescence , physics , quantum mechanics , enzyme
Herein, we report on the synthesis of PEG‐1000‐diethyl ester and 2‐azido‐propane‐1,3‐diol‐based copolymers utilizing Novozym 435 ( Candida antarctica lipase) using a biocatalytic method. The linear base copolymer was then functionalized with polyglycerol‐based regular [G1.0] and [G2.0] dendrons and C 12 /C 14 hydrophobic alkyl chains via an efficient “Click approach.” The resulting amphiphilic dendronized polymers form well‐defined micelles in aqueous solutions. The transport behavior of these polymers was studied by using Nile red as a fluorescent model dye. The cytotoxicity profiles of a few representative polymers were evaluated, and the effect of hydrophobic alkyl chain length as well as the hydrophilic polyglycerol dendron's generation on the biocompatibility of polymeric systems was studied. Copyright © 2014 John Wiley & Sons, Ltd.