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Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network
Author(s) -
Farah Shady,
Aviv Oren,
Laout Natalia,
Ratner Stanislav,
Beyth Nurit,
Domb Abraham J.
Publication year - 2014
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3260
Subject(s) - polyethylenimine , materials science , ammonium , ethylene glycol , methacrylic acid , methacrylate , particle size , nuclear chemistry , polymer chemistry , chemical engineering , organic chemistry , copolymer , polymer , chemistry , composite material , transfection , biochemistry , engineering , gene
Silica particles functionalized with quaternary ammonium groups were prepared by interpenetrating polyethylenimine (PEI) into silica particles and crosslinking with diiodopentane, followed by octyliodide alkylation and methyliodide quaternarization (S‐QA‐PEI). The synthesized S‐QA‐PEI particles were identified with a slight particle size increase of 2–3 µm. Different ratios of PEI:silica particles were prepared and analyzed. While silica particles are negatively charged, −16.7 ± 5.11 mV, the prepared S‐QA‐PEI particles are positively charged, +50–60 mV. These particles were embedded in poly(ethylene vinyl acetate) and poly(ethylene methacrylic acid) coatings which exhibited strong antibacterial activity. Copyright © 2014 John Wiley & Sons, Ltd.