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Highly porous poly(lactide‐ co ‐glycolide) microparticles for sustained tiotropium release
Author(s) -
Park SoHyun,
Kwag Dong Sup,
Lee Ung Yeol,
Lee Dong Jin,
Oh Kyung Taek,
Youn Yu Seok,
Lee Eun Seong
Publication year - 2014
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3198
Subject(s) - plga , ammonium bicarbonate , materials science , controlled release , emulsion , particle size , chemical engineering , chromatography , chemistry , nanoparticle , organic chemistry , nanotechnology , engineering , raw material
In this study, porous poly(lactide‐ co ‐glycolide) (PLGA) microparticles with low mass density and large particle size were developed for chronic obstructive pulmonary disease treatment using anticholinergic drug (tiotropium). The porous PLGA microparticles were prepared by the water‐in‐oil‐in‐water (W 1 /O/W 2 ) multi‐emulsion method using PLGA polymer and ammonium bicarbonate (as a porogen). Herein, soluble starch was incorporated in porous PLGA microparticles for long‐term tiotropium release. In vitro drug release studies determined that the rapid release of tiotropium from porous PLGA microparticles was reduced because of the high viscosity of the incorporated starch. Tiotropium release from porous PLGA microparticles continued up to 3 days. Furthermore, the inhaled microparticles showed longer drug residence in in vivo lung epithelium. Copyright © 2013 John Wiley & Sons, Ltd.