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Gas‐forming poly(ethylene glycol)‐ b ‐poly(L‐lactic acid) micelles
Author(s) -
Lee Jung Ok,
Kim Dongin,
Kwag Dong Sup,
Lee Ung Yeol,
Oh Kyung Taek,
Youn Yu Seok,
Oh Young Taik,
Park Jin Woo,
Lee Eun Seong
Publication year - 2013
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3116
Subject(s) - micelle , ethylene glycol , materials science , aqueous solution , lactic acid , polymer chemistry , ethylene carbonate , hydrolysis , copolymer , carbonate , chemical engineering , organic chemistry , chemistry , polymer , electrode , electrolyte , biology , bacteria , engineering , composite material , genetics , metallurgy
In this study, a novel drug‐carrying micelle composed of methoxy poly(ethylene glycol) (mPEG)‐ b ‐poly(L‐lactic acid) (PLLA) with gas‐forming carbonate linkage was fabricated. Here, the gas‐forming carbonate linkage was formed by the chemical coupling of the terminal hydroxyl group of the PLLA block and benzyl chloroformate (BC). mPEG‐ b ‐PLLA‐BC was self‐organized in aqueous solution: the PEG block on the hydrophilic outer shell and the PLLA‐BC block in the hydrophoboic innor core. The cleavage of carbonate linkage by hydrolysis and formation of carbon dioxide nanobubbles in the micellar core enabled an accelerated release of the encapsulated anticancer drug (doxorubicin: DOX) from the mPEG‐ b ‐PLLA‐BC micelles. The amount of drug (DOX) released from the mPEG‐ b ‐PLLA‐BC micelle was higher than that from the conventional mPEG‐ b ‐PLLA micelle, which allowed for increased in vitro toxicity against KB tumor cells. Copyright © 2013 John Wiley & Sons, Ltd.