Premium
Crosslinked QA‐PEI nanoparticles: synthesis reproducibility, chemical modifications, and stability study
Author(s) -
Farah Shady,
Khan Wahid,
Farber Ira,
KeslerShvero Dana,
Beyth Nurit,
Weiss Ervin I.,
Domb Abraham J.
Publication year - 2013
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.3102
Subject(s) - polyethylenimine , reproducibility , materials science , nanoparticle , thermal stability , ammonium iodide , particle size , chemical stability , ammonium , nuclear chemistry , chemical engineering , nanotechnology , organic chemistry , chemistry , chromatography , transfection , biochemistry , engineering , gene
Quaternary ammonium polyethylenimine (QA‐PEI) nanoparticles were synthesized by PEI crosslinking and alkylation with octyliodide followed by quaternization by methyl iodide. The present study focuses on the reproducibility of particles formation with respect to particle size, positive charge, oxidative, thermal stability and antibacterial activity. The QA‐PEI‐based nanoparticles with particle size in the range of 160–190 nm were synthesized in high reproducibility and showed high chemical stability against environmental changes including exposure to different oxidizers and storage conditions. QA‐PEI nanoparticles incorporated in dental restorative resin composites at 2% w/w demonstrated strong antibacterial activity. Copyright © 2013 John Wiley & Sons, Ltd.