Enzymatically controlled responsive drug delivery systems | Zendy

Goldbart Riki | Zendy; Traitel Tamar | Zendy; Lapidot Smadar A. | Zendy; Kost Joseph | Zendy

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Enzymatically controlled responsive drug delivery systems

Author(s) -

Goldbart Riki,

Traitel Tamar,

Lapidot Smadar A.,

Kost Joseph

Publication year - 2002

Publication title -

polymers for advanced technologies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.61

H-Index - 90

eISSN - 1099-1581

pISSN - 1042-7147

DOI - 10.1002/pat.275

Subject(s) - glucose oxidase , drug delivery , methacrylate , starch , drug , hydrolysis , enzyme , combinatorial chemistry , controlled release , calcium , ether , materials science , chemistry , organic chemistry , nanotechnology , pharmacology , copolymer , biology , polymer

This paper discusses two approaches for the preparation of enzymatically controlled drug delivery systems: (i) a calcium‐responsive biodegradable drug delivery system based on a mixture of starch with HPMC (hydroxypropyl methyl cellulose ether) (biodegradable) and the starch hydrolytic enzyme, α‐amylase, in its non‐active form; (ii) a glucose‐responsive insulin delivery system based on the hydrogel poly(2‐hydroxyethyl methacrylate‐co‐N,N‐dimethylaminoethyl methacrylate), with entrapped glucose oxidase, catalase and insulin. In both systems, the sensitivity to a trigger molecule (calcium or glucose) was achieved by the incorporation of a specific enzyme that reacts with the trigger molecule. Based on these interactions we propose two different enzyme‐controlled drug release mechanisms for responsive drug delivery systems. Copyright © 2003 John Wiley & Sons, Ltd.

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