Premium
Enzymatically controlled responsive drug delivery systems
Author(s) -
Goldbart Riki,
Traitel Tamar,
Lapidot Smadar A.,
Kost Joseph
Publication year - 2002
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.275
Subject(s) - glucose oxidase , drug delivery , methacrylate , starch , drug , hydrolysis , enzyme , combinatorial chemistry , controlled release , calcium , ether , materials science , chemistry , organic chemistry , nanotechnology , pharmacology , copolymer , biology , polymer
This paper discusses two approaches for the preparation of enzymatically controlled drug delivery systems: (i) a calcium‐responsive biodegradable drug delivery system based on a mixture of starch with HPMC (hydroxypropyl methyl cellulose ether) (biodegradable) and the starch hydrolytic enzyme, α‐amylase, in its non‐active form; (ii) a glucose‐responsive insulin delivery system based on the hydrogel poly(2‐hydroxyethyl methacrylate‐co‐N,N‐dimethylaminoethyl methacrylate), with entrapped glucose oxidase, catalase and insulin. In both systems, the sensitivity to a trigger molecule (calcium or glucose) was achieved by the incorporation of a specific enzyme that reacts with the trigger molecule. Based on these interactions we propose two different enzyme‐controlled drug release mechanisms for responsive drug delivery systems. Copyright © 2003 John Wiley & Sons, Ltd.