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Interactions between temperature‐sensitive hydrogel microspheres and granulocytes
Author(s) -
Achiha Koji,
Ojima Rika,
Kasuya Yuji,
Fujimoto Keiji,
Kawaguchi Haruma
Publication year - 1995
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1995.220060715
Subject(s) - lower critical solution temperature , materials science , microsphere , chemical engineering , poly(n isopropylacrylamide) , adhesion , oxygen , polymer chemistry , composite material , polymer , chemistry , copolymer , organic chemistry , engineering
Abstract Poly(N‐isopropylacrylamide) (PNIPAM) has a low critical solution temperature (LCST) at 32°C in water and the hydrophilicity changes through the LCST. The microspheres whose surface was composed of PNIPAM exhibited phase transition behavior around 32°C. Therefore, the interactions between PNIPAM micropheres and granulocytes depended on the temperature. That is, the oxygen consumption and active oxygen production by cells in contact with PNIPAM‐containing microspheres and adhesion of the microspheres to the cell surface were more enhanced above the LCST of PNIPAM than below it, whereas no significant temperature dependence of cell–microspheres interaction was observed in nonthermosensitive microsphere systems. It was suggested that the function of cells could be controlled with temperature using the temperature‐sensitive microspheres.