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Development of natural product (1 → 3)‐β‐ D ‐glucan polymers as immune‐stimulating pharmaceuticals
Author(s) -
Williams David L.,
Browder I. William
Publication year - 1994
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1994.220050910
Subject(s) - glucan , immune system , phosphate , immunosuppression , pharmacology , materials science , medicine , immunology , chemistry , biochemistry
Glucan phosphate is a water‐soluble, yeast‐derived, (1 → 3)‐β‐D‐glucopyranose polymer that has been demonstrated to be a potent immune stimulant. Glucan phosphate administration is associated with stimulation of immunity and a concomitant increase in resistance to a variety of experimentally induced disease states. Preclinical safety evaluation indicates that glucan phosphate does not induce mortality or significant toxicity over a wide dose range. Phase I clinical data indicate that glucan phosphate will ameliorate immunosuppression, stimulate immunity, decrease susceptibility to infection and alter ultimate outcome in trauma patients following laparotomy or thoracotomy. This work reviews the development, characterization, preclinal and clinical evaluation of glucan phosphate.