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Novel graft copolymers for in vivo targeting of colloidal carriers
Author(s) -
Arshady R.,
Illum L.,
Davis S. S.
Publication year - 1990
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1990.220010510
Subject(s) - materials science , copolymer , in vivo , nanocapsules , colloid , nanometre , mononuclear phagocyte system , nanotechnology , drug carrier , chemical engineering , polymer chemistry , nanoparticle , drug delivery , polymer , composite material , medicine , microbiology and biotechnology , engineering , immunology , biology
A series of novel graft (comb) copolymers composed of a hydrophobic backbone and hydrophilic side chain grafts are described for the in vivo targeting of colloidal carriers. The new copolymers, when coated on nanometer size particles (nanospheres, nanocapsules), substantially reduce the capture of the particles by the reticuloendothelial system (RES) and show potential for targeting to the bone marrow.