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Synthesis and characterization of amphiphilic antibacterial copolymers
Author(s) -
Bai Yong Xiao,
Liu Yao Bin,
Li Yan Feng,
Zhang Qi
Publication year - 2012
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1928
Subject(s) - amphiphile , raft , copolymer , materials science , polymer , chain transfer , antibacterial activity , biocide , polymerization , antimicrobial , styrene , macromolecule , polymer chemistry , combinatorial chemistry , nanotechnology , chemical engineering , organic chemistry , radical polymerization , chemistry , bacteria , biology , composite material , genetics , biochemistry , engineering
Macromolecule antimicrobials have been explored in foundational research and practical application due to their potential merit for reducing the residual toxicity, increasing their efficiency, selectivity, and prolonging the lifetime of the antimicrobial material. In this work, the quaternized poly(styrene)‐ b ‐poly(DMAEMA) diblock polymers are synthesized by reversible addition‐fragmentation chain transfer polymerization (RAFT). The minimum inhibitory concentration (MIC) evaluation and optical density (OD) method demonstrated that the amphiphilic antibacterial biomaterials have exceptional antibacterial properties. The amphiphilic polycation has an admirable antibacterial property, and these quaternized diblocks are potent biocides and nonhemolytic. The relationship between the structure and activity is discussed with respect to molecular weight of the diblocks and bacteria structural dependence. Copyright © 2011 John Wiley & Sons, Ltd.