Premium
β ‐Cyclodextrin hydrogel incorporating hydrophobically modified poly( N ‐isopropylacrylamide) for a temperature‐dependent release
Author(s) -
Lee Mi Sun,
Kim JinChul
Publication year - 2012
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1893
Subject(s) - self healing hydrogels , poly(n isopropylacrylamide) , cyclodextrin , materials science , swelling , polymer chemistry , chemical engineering , polymer , dextran , copolymer , chemistry , composite material , organic chemistry , engineering
Hydrogels exhibiting a temperature‐dependent release were prepared by incorporating hydrophobically modified poly( N ‐isopropylacrylamide) (HmPNIPAM) into β ‐cyclodextrin hydrogels ( β ‐CD hydrogels). The specific loading of HmPNIPAM was about 0.0069 g HmPNIPAM/g β ‐CD hydrogels. The incorporation of the polymer was qualitatively conformed by FT‐IR spectroscopy and SEM. The percent release of blue dextran in 24 hr at 20°C (about 77%) was markedly higher than those obtained at 35°C and 45°C (about 53 and 55%, respectively). At the higher temperatures, the volume of the hydrogel could decrease upon the thermal contraction of HmPNIPAM, leading to a smaller mesh and a suppressed release. In fact, the swelling ratio in 24 hr at 35°C and 45°C (about 396% and 405%, respectively) was obviously lower than that obtained at 20°C (about 465%). Copyright © 2011 John Wiley & Sons, Ltd.