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Phase separation of polyphosphazene/poly(lactide‐ co ‐glycolide) blends prepared under different conditions
Author(s) -
Cai Qing,
Wang Ying,
Yang Fei,
Shen Hong,
Yang Xiaoping,
Wang Shenguo
Publication year - 2011
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1783
Subject(s) - materials science , x ray photoelectron spectroscopy , chemical engineering , plga , solvent , scanning electron microscope , polymer chemistry , dichloromethane , tetrahydrofuran , phenolphthalein , anhydrous , morphology (biology) , ethyl acetate , contact angle , nuclear chemistry , composite material , organic chemistry , chemistry , nanotechnology , nanoparticle , engineering , biology , genetics
Using a mutual solvent technique, blend films of poly[(alaine ethyl ester) 0.62 (glycine ethyl ester) 0.38 ]phosphazene/poly(lactide‐ co ‐glycolide) (PAGP/PLGA blend) were prepared at different conditions including weight ratios, solvents, environmental humidity, film thickness, and substrates. The morphology and properties of blend films were characterized by scanning electron microscope (SEM), energy dispersive spectrometer (EDX), X‐ray photoelectron spectrometry (XPS), and solvent selective etching. Compared with dichloromethane and tetrahydrofuran (THF), chloroform was the better solvent to form miscible PAGP/PLGA blend films at relatively anhydrous atmosphere. However, in the humid atmosphere, the hexagonal arrangement of holes appeared on the surface of PAGP/PLGA blend films due to the ordered array of water droplets. A sandwich‐liked structure was formed with the hydrophilic PAGP component at the top and bottom, while the PLGA component in the middle. In addition, the surface morphology of PAGP/PLGA blend films was also influenced by the film thickness and the property of the substrate. Copyright © 2010 John Wiley & Sons, Ltd.