Premium
A biocompatible composite based on poly( ε ‐caprolactone fumarate) and hydroxyapatite
Author(s) -
Shafieyan Yousef,
Sharifi Shahriar,
Imani Mohammad,
Shokrgozar Mohammad Ali,
Aboudzadeh Neda,
Atai Mohammad
Publication year - 2011
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1743
Subject(s) - materials science , polycaprolactone , caprolactone , gel permeation chromatography , fourier transform infrared spectroscopy , composite material , biocompatibility , curing (chemistry) , polymer , chemical engineering , polymer chemistry , polymerization , engineering , metallurgy
Fabrication of biodegradable composites applicable as hard tissue substitutes consisting of poly(ε‐caprolactone fumarate) (PCLF), methacrylic acid (MAA), and hydroxyapatite (HA) was investigated. PCLF macromers were synthesized by reaction of PCL diol with fumaryl chloride in the presence of propylene oxide and characterized by gel permeation chromatography, FTIR, and 1 H NMR spectroscopy. Composites were fabricated by incorporating HA as inorganic filler in PCLF matrix which followed by thermal curing of the composition using benzoyl peroxide and MAA as a free radical initiator and reactive diluent, respectively. Uniform distribution of the fine ceramic phase in the polymer matrix was elucidated by scanning electron microscopy. The effects of the initial macromer molecular weight and the filler volume fraction on mechanical properties and cytotoxicity of the composites were also examined. Significant enhancement in the mechanical properties was observed upon increasing HA content and/or initial PCLF molecular weight. The biocompatibility of the specimens was also improved with increasing ceramic phase. Copyright © 2010 John Wiley & Sons, Ltd.