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Synthesis and characterization of pH‐sensitive PAMPS/PVP nanogels in aqueous media
Author(s) -
Atta Ayman M.,
ElGhazawy Rasha A. M.,
Farag Reem K.,
Elsaeed Shymaa M.
Publication year - 2011
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1573
Subject(s) - nanogel , sulfonic acid , monomer , polymerization , aqueous solution , materials science , polymer chemistry , swelling , chemical engineering , nanoparticle , nuclear chemistry , drug delivery , chemistry , polymer , organic chemistry , nanotechnology , engineering , composite material
A novel method for preparing poly (2‐acrylamido‐2‐methylpropane sulfonic acid) (PAMPS) and poly (vinylpyrrolidone) (PVP) complex nanogels in PVP aqueous solution is discussed in this paper. The PAMPS/PVP complex nanogels were prepared via polymerization of 2‐acrylamido‐2‐methylpropane sulfonic acid (AMPS) monomer in the presence of PVP nanoparticles which formed in water/acetone cosolvent in presence of N , N ′‐methylenebisacrylamide (MBA) as a crosslinker, N , N , N ′, N ′‐tetramethylethylenediamine (TEMED) and potassium peroxydisulfate (KPS) as redox initiator system. The results of FTIR and 1 H NMR spectra indicated that the compositions of PAMPS/PVP are consistent with the designed structure. TEM micrographs proved that PAMPS/PVP nanogels possess the spherical morphology before and after swelling. These PAMPS/PVP nanogels exhibited pH‐induced phase transition due to protonation of PAMPS chains. The properties of PAMPS/PVP nanogels indicate that PAMPS/PVP nanogels can be developed into a pH‐controlled drug delivery system. Copyright © 2009 John Wiley & Sons, Ltd.