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Methoxy poly(ethylene glycol)‐ b ‐poly(octadecanoic anhydride)‐ b ‐methoxy poly(ethylene glycol) amphiphilic triblock copolymer nanoparticles as delivery vehicles for paclitaxel
Author(s) -
Xing Jinfeng,
Deng Liandong,
Xie Chaopeng,
Xiao Li,
Zhai Yinglei,
Jin Fengmin,
Li Yimei,
Dong Anjie
Publication year - 2011
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1563
Subject(s) - ethylene glycol , copolymer , dispersity , amphiphile , materials science , polymer chemistry , drug delivery , nanoparticle , nuclear chemistry , organic chemistry , chemistry , polymer , nanotechnology , composite material
Abstract A series of amphiphilic triblock copolymers, methoxy poly(ethylene glycol)‐ b ‐poly(octadecanoic anhydride)‐ b ‐methoxy poly(ethylene glycol) (mPEG‐ b ‐POA‐ b ‐mPEG), were prepared via melt polycondensation of methoxy poly(ethylene glycol) (mPEG) and poly(octadecanoic anhydride) (POA). mPEG‐ b ‐POA‐ b ‐mPEG were characterized by FTIR, 1 H‐NMR, GPC, DSC, and XRD. Drug‐loaded mPEG‐ b ‐POA‐ b ‐mPEG nanoparticles (NPs) with spherical morphology and narrow size polydispersity index were prepared by nanoprecipitation technique with paclitaxel as the model drug. In vitro release behaviors of drug‐loaded NPs present that the biphasic process and the release mechanism of each phase are zero order drug releases. According to this study, mPEG‐ b ‐POA‐ b ‐mPEG NPs could serve as suitable delivery agents for paclitaxel and other hydrophobic drugs. Copyright © 2009 John Wiley & Sons, Ltd.