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Thermo‐sensitive amphiphilic poly( N ‐vinylcaprolactam) copolymers: synthesis and solution properties
Author(s) -
Zhang Lifen,
Liang Yong,
Meng Lingzhi
Publication year - 2010
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1495
Subject(s) - copolymer , aqueous solution , materials science , polymer chemistry , amphiphile , micelle , cloud point , polymer , monomer , lower critical solution temperature , thermoresponsive polymers in chromatography , chemical engineering , chemistry , organic chemistry , phase (matter) , reversed phase chromatography , engineering , composite material
Thermo‐sensitive amphiphilic copolymers, PVCL‐PTrpAMT and PVCL‐PVP‐PTrpAMT of hydrophilic N ‐vinylcaprolactam (VCL), N ‐vinylpyrrolidone (NVP), and hydrophobic N ‐ t ‐Boc‐tryptophanamido‐ N ′‐methacryl thioureas (TrpAMT) monomers, were synthesized and characterized by 1 H NMR, UV‐spectroscopy, and GPC‐MALLS. The cloud point (CP) measurement showed that hydrophobic PTrpAMT and hydrophilic PVP segments significantly altered the phase transition temperature of PVCL with comparable molecular weight in aqueous solution. The CP of PVP‐PTrpAMT solution was 38.0°C, lower by 5.0°C than that of unmodified PVCL. In the presence of phosphate buffer saline (PBS), the CP value of the PVCL polymer decreased by ∼2.0°C in comparison to that of the aqueous solution. Fluorescent spectroscopy and TEM studies revealed that PVCL‐PTrpAMT and PVCL‐PVP‐PTrpAMT self‐assembled into the spherical micelles, 30–70 nm in diameter, at concentrations over their CMCs in an aqueous solution. Cytotoxicity tests demonstrated that the PVCL copolymers were not harmful to cell viability, which may favor the use of the copolymers as potential thermo‐sensitive polymers in pharmaceutical applications. Copyright © 2009 John Wiley & Sons, Ltd.

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