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Preparation of albumin—PAA nanocapsules and their controlled release behavior for drugs
Author(s) -
Wang RongMin,
Li Gang,
Zhang HuiFang,
He YuFeng,
He NaiPu,
Lei Ziqiang
Publication year - 2010
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1481
Subject(s) - nanocapsules , materials science , bovine serum albumin , polymerization , nanoparticle , doxorubicin hydrochloride , zeta potential , swelling , controlled release , polymer chemistry , in situ polymerization , biopolymer , acrylic acid , dynamic light scattering , chemical engineering , nuclear chemistry , polymer , doxorubicin , nanotechnology , chromatography , chemistry , copolymer , composite material , medicine , surgery , engineering , chemotherapy
New kinds of narrowly distributed protein‐based nanoparticles, bovine serum albumin‐Poly (acrylic acid) (BSA/PAA) nanospheres, and nanocapsules were prepared via in situ polymerization, swelling, and re‐aggregation. The structure and morphology of the nanospheres were characterized by UV‐Vis, FT‐IR, DLS, and TEM. The stability of the BSA/PAA nanospheres and nanocapsules was increased when their skeletons were fixed by cross‐linked agents. The nanospheres carried a positive charge and their size was about 80–110 nm. The protein‐based nanocapsules were stimuli‐responsive with pH value and their hydrodynamic diameter varied from 70 to 230 nm with changes of pH. In vitro release experiments of Rhodamine B and Doxorubicin hydrochloride showed that these biopolymer nanoparticles provided a controlled release of the entrapped drugs for 300 hr. Copyright © 2009 John Wiley & Sons, Ltd.
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