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Synthesis, characterization, and drug release behaviors of a novel thermo‐sensitive poly( N ‐acryloylglycinates)
Author(s) -
Deng Kuilin,
Zhong Haibin,
Zheng Xiangyang,
Song Xiaohui,
Tian Hua,
Zhang Pengfei,
Ren Xiaobo,
Wang Haijun
Publication year - 2010
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1471
Subject(s) - lower critical solution temperature , self healing hydrogels , materials science , polymer , acrylamide , aqueous solution , fourier transform infrared spectroscopy , swelling , monomer , polymer chemistry , salt (chemistry) , nuclear chemistry , chemical engineering , chemistry , organic chemistry , engineering , copolymer , composite material
In this study, a novel thermo‐sensitive poly( N ‐acryloylglycinates) was prepared in order to get a potential drug release carrier. The corresponding monomers and the polymers were characterized with Fourier‐transform infrared (FTIR) and 1 H NMR. The thermo‐sensitivity of the poly( N ‐acryloylglycinates) was evaluated by measuring their lower critical solution temperatures (LCST) in water, inorganic salt solution, and different pH solutions. The results indicated that poly( N ‐acryloylglycine methyl ester) (NAGME) and poly( N ‐acryloylglycine ethyl ester) (NAGEE) exhibit a reversible thermo‐sensibility in their aqueous solutions at 61.5 and 12.5°C, respectively. However, no thermo‐sensitive behavior of poly( N ‐acryloylglycine propyl ester) (NAGPE) was found due to its over hydrophobicity. The swelling studies on hydrogels were carried out at different temperatures, in different pH, and inorganic salt solutions. The hydrogels showed a remarkable phase transition at about 35°C with changing temperature. The release rate of caffeine from the thermo‐sensitive hydrogel was apparently decreased as the crosslinker content increased and temperature decreased. Seventy five percent caffeine from the polymeric hydrogel with 5% NMBA ( N, N ‐methylenebis(acrylamide)) was released at room temperature within 240 min, whereas 95.4% caffeine diffused into the medium at 37°C. Copyright © 2009 John Wiley & Sons, Ltd.