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Effect of immobilization of polysaccharides on the biocompatibility of poly(butyleneadipate‐ co ‐terephthalate) films
Author(s) -
Jao WinChun,
Lin ChienHong,
Hsieh JuiYuan,
Yeh YiHsing,
Liu ChiaYi,
Yang MingChien
Publication year - 2010
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1459
Subject(s) - biocompatibility , materials science , x ray photoelectron spectroscopy , adsorption , atomic force microscopy , chitosan , nuclear chemistry , protein adsorption , human serum albumin , chemical engineering , contact angle , polymer chemistry , nanotechnology , polymer , chemistry , organic chemistry , chromatography , composite material , engineering , metallurgy
Aiming to improve the hydrophilicity, antibacterial activity, cytocompatibility, and hemocompatibility of poly(butyleneadipate‐ co ‐terephthalate) (PBAT) films, PBAT films were treated with ozone, grafted with chitosan (CS), and followed by covalent immobilization of either heparin (HEP) or hyaluronic acid (HA). The surface graft density of modified PBAT films was detected by X‐ray photoelectron spectroscopy (XPS) and dyeing. The surface roughness of PBAT films was measured using an atomic force microscope (AFM). After immobilizing CS, PBAT films acquired antibacterial activity against Staphylococcus aureus and Escherichia coli . The adsorption of human serum albumin (HSA) and human plasma fibrinogen (HPF) on PBAT–CS–HEP and PBAT–CS–HA films was lower compared to that of native PBAT. Moreover, HEP immobilization could effectively reduce platelet adhesion and prolong the blood coagulation time, thereby improving the blood compatibility of PBAT. In addition, the growth of L929 fibroblasts was improved for HEP or HA immobilized PBAT, suggesting this surface modification was non‐cytotoxic. Furthermore, PBAT–CS–HEP and PBAT–CS–HA exhibited higher cell proliferation than native PBAT. Copyright © 2009 John Wiley & Sons, Ltd.