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Fabrication of biodegradable poly(trimethylene carbonate) networks for potential tissue engineering scaffold applications
Author(s) -
Zhang C.,
Subramanian H.,
Grailer J. J.,
Tiwari A.,
Pilla S.,
Steeber D. A.,
Gong S.
Publication year - 2009
Publication title -
polymers for advanced technologies
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.61
H-Index - 90
eISSN - 1099-1581
pISSN - 1042-7147
DOI - 10.1002/pat.1334
Subject(s) - trimethylene carbonate , biocompatibility , tissue engineering , materials science , photopolymer , ring opening polymerization , scaffold , macromonomer , polymer chemistry , carbonate , polymerization , biomedical engineering , composite material , polymer , medicine , metallurgy
Biodegradable poly(trimethylene carbonate) (PTMC) networks were prepared by photopolymerization of linear (L)‐ and star (S)‐shaped PTMC macromonomers for potential tissue engineering scaffold applications. The L‐ ( M n , 6400) and S‐shaped ( M n , 5880) PTMC macromonomers were synthesized using 1,4‐butane diol and 2‐ethyl‐ 2‐hydroxyl‐propane‐1,3‐diol co‐initiated ring‐opening polymerization of trimethylene carbonate (TMC) in the presence of stannous octoate and subsequent acrylation with acryloyl chloride. Chemical structures of the PTMC macromonomers and their corresponding networks were characterized by 1 H NMR and 13 C NMR spectroscopy. The human endothelial cell line, EA.hy926 was used to test the biocompatibility, cell adhesion, and proliferation behavior of both PTMC networks. The PTMC networks made from the S‐shaped macromonomers exhibited superior cell adhesion and proliferation behavior than those made of the linear macromonomers. Copyright © 2008 John Wiley & Sons, Ltd.